Prediction of cardiovascular risk using soluble cell adhesion molecules

Prediction of cardiovascular risk using soluble cell adhesion molecules.

Inflammation is now considered a critical pathogenic component of the atherosclerotic process. This is characterized histopathologically by leukocyte infiltration of the vascular endothelial wall. The vascular endothelium is a dynamic organ system, which has natural antiadhesive and anticoagulant properties. However, in response to injury the endothelium promotes coagulation and mediates the bi...

Risk stratification in unstable angina and non-Q wave myocardial infarction using soluble cell adhesion molecules.

OBJECTIVE To assess prospectively the prognostic value of soluble cellular adhesion molecules (CAMs) in patients with unstable angina and non-Q wave myocardial infarction and to compare their prognostic accuracy with that of C reactive protein (CRP). DESIGN AND SETTING Prospective observational study of patients presenting acutely with unstable angina and non-Q wave myocardial infarction to a...

Soluble Vascular Cell Adhesion Molecules May be Protective of Future Cardiovascular Disease Risk: Findings from the PREVEND Prospective Cohort Study

AIM Soluble cell adhesion molecules, such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1, E-selectin, and P-selectin, have been suggested to be associated with cardiovascular disease (CVD) risk; however, the nature and magnitude of the association between VCAM-1 and CVD risk is uncertain. We aimed to assess the association of VCAM-1 with CVD risk and determine ...

Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk.

OBJECTIVES The purpose of this study was to evaluate whether soluble vascular cell adhesion molecule-1 (sVCAM-1) is a marker for increased cardiovascular risk. BACKGROUND Soluble forms of cellular adhesion molecules (CAMs) may be useful markers of endothelial activation and local or systemic inflammation. Recent studies indicate that plasma concentration of soluble intercellular adhesion mole...

Soluble adhesion molecules in ischaemic heart disease.